Fertility Drugs and Pregnancy Risks: What You Need to Know
Jan. 4, 2026, 6:38 a.m.
Overview
Many couples face infertility, affecting about one in six people trying to conceive. Fertility drugs help many achieve pregnancy, but they come with risks. This guide covers common fertility drugs and pregnancy risks, helping you make informed choices.

Infertility touches millions worldwide. You feel excited yet worried when starting treatments. Fertility drugs stimulate ovulation or support procedures like IVF. They work well but raise questions about safety during pregnancy.
Doctors prescribe these medications to women who do not ovulate regularly or need extra help. Common ones include oral pills like Clomid and injectable gonadotropins.
Common Fertility Drugs
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Clomiphene Citrate (Clomid): This oral drug tricks your body into producing more follicle-stimulating hormone (FSH). It helps release eggs and serves as a first-step treatment for many.
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Letrozole: Doctors often use this for similar purposes, especially in women with PCOS.
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Gonadotropins: These injectable drugs contain FSH and LH. They stimulate ovaries directly and see frequent use in IVF.
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hCG (human chorionic gonadotropin): This triggers final egg release.
These drugs boost your chances of getting pregnant. Many women conceive within a few cycles. Success feels amazing after months or years of trying.
Key Risks: Multiple Pregnancies
The biggest concern with fertility drugs and pregnancy risks involves multiples—twins, triplets, or more.
Oral drugs like Clomid carry a lower risk, around 5-10% for twins according to the Mayo Clinic's guide on female infertility treatment. Injectable gonadotropins raise it higher, sometimes up to 30%.
Multiples sound fun, but they increase chances of:
- Preterm birth
- Low birth weight
- Preeclampsia
- Cesarean delivery

Doctors monitor you closely with ultrasounds to count growing follicles. They may cancel a cycle or adjust doses if too many eggs develop.
In IVF, transferring one embryo at a time reduces this risk greatly.
Ovarian Hyperstimulation Syndrome (OHSS)
OHSS happens when ovaries overrespond to drugs. They swell and leak fluid.
Symptoms range from mild bloating to severe pain, nausea, and shortness of breath. Severe cases are rare but require hospital care.
Risk is higher with injectables. The American Society for Reproductive Medicine notes close monitoring helps prevent serious OHSS.
Other Potential Risks
- Ectopic Pregnancy: Slightly higher chance, especially if you have tubal issues.
- Birth Defects: Studies show no major increase linked directly to drugs.
- Long-term Cancer Risk: Early worries about ovarian cancer existed, but recent reviews from the National Institutes of Health find no clear link after accounting for infertility itself.
Many women share stories of smooth treatments with healthy babies. One friend took Clomid, got twins, and managed well with extra prenatal care. Risks exist, but doctors manage them effectively.
Managing Stress During Fertility Treatments
Treatments bring emotional ups and downs. You feel hopeful one day and anxious the next.
Here are actionable ways to cope:
- Practice mindfulness or yoga daily
- Join support groups—online or in-person
- Talk openly with your partner
- Consider counseling if stress feels overwhelming
Managing stress during fertility treatments improves your well-being and may even boost success rates.

Exercise lightly, eat nourishing foods, and get enough sleep. Small steps make a big difference.
Tips for a Safer Journey
- Choose an experienced clinic with good monitoring.
- Ask about single embryo transfer in IVF.
- Follow instructions carefully.
- Report side effects right away.
The Centers for Disease Control and Prevention ART reports provide data on clinic success and multiple rates—check them when selecting a provider.
Fertility drugs help countless families grow. While risks like multiples and OHSS exist, careful medical oversight keeps most treatments safe. Weigh benefits against risks with your doctor. Stay informed, manage stress, and hold onto hope. Many achieve healthy pregnancies.